Roger's Medical Corner
Here's a bit of news for all those bashers of Canadian "socialized medicine." A group of Toronto doctors and researchers at the Hospital for Sick Children, Research Institute report the following:
In type 1 diabetes, T cell-mediated death of pancreatic β cells produces insulin deficiency. However, what attracts or restricts broadly autoreactive lymphocyte pools to the pancreas remains unclear. We report that TRPV1+ pancreatic sensory neurons control islet inflammation and insulin resistance. Eliminating these neurons in diabetes-prone NOD mice prevents insulitis and diabetes, despite systemic persistence of pathogenic T cell pools. Insulin resistance and β cell stress of prediabetic NOD mice are prevented when TRPV1+ neurons are eliminated. TRPV1NOD, localized to the Idd4.1 diabetes-risk locus, is a hypofunctional mutant, mediating depressed neurogenic inflammation. Delivering the neuropeptide substance P by intra-arterial injection into the NOD pancreas reverses abnormal insulin resistance, insulitis, and diabetes for weeks. Concordantly, insulin sensitivity is enhanced in trpv1−/− mice, whereas insulitis/diabetes-resistant NODxB6Idd4-congenic mice, carrying wild-type TRPV1, show restored TRPV1 function and insulin sensitivity. Our data uncover a fundamental role for insulin-responsive TRPV1+ sensory neurons in β cell function and diabetes pathoetiology.
Or, in terms understandable too those simpletons who parrot Rush Limbaugh, Mallard Fillmore and The Corner without engaging their brains:
"In a discovery that has stunned even those behind it, scientists at a Toronto hospital say they have proof the body's nervous system helps trigger diabetes, opening the door to a potential near-cure of the disease that affects millions of Canadians.
"Diabetic mice became healthy virtually overnight after researchers injected a substance to counteract the effect of malfunctioning pain neurons in the pancreas.
"'I couldn't believe it,' said Dr. Michael Salter, a pain expert at the Hospital for Sick Children and one of the scientists. 'Mice with diabetes suddenly didn't have diabetes any more.'" (Link added.)
Meanwhile, fucking American hospitals can't even fucking bill their patients correctly.