"[Hillary Clinton] reports in one letter from October of her sophomore year that she spent a 'miserable weekend' arguing with a friend who believed that 'acid is the way and what did I have against expanding my conscience.'"to suggest that the future senator was urging the letter's recipient to drop acid, as opposed to recounting a dispute in which her friend advocated LSD to Clinton.
I'm sure Media Matters or someone else will have more on this.
I'd probably like Senator Clinton more if she had taken acid (which even may have been legal back then). But this goes to show how the Republicans and their lackeys will grasp at anything to smear a Democratic frontrunner.